Flurbiprofen is non-steroidal anti-inflammatory agents (NSAIAs) which has low oral bio availability due to high first pass metabolism and shorter half-life which leads to higher dosing frequency. Microspheres with release retardant polymers are expected to sustain the release of drug. In the present study microsphere entrapped with flurbiprofen were prepared and characterized with aim to achieve sustained release. Microspheres were prepared by emulsion solvent evaporation method using various polymers such as ethyl cellulose (EC), (hydroxyl propyl methyl cellulose) HPMC E50LV, HPMC K100M. The prepared microspheres were characterized for the in-vitro release, percentage practical yield, particle size, drug entrapment efficiency and scanning electron microscopy (SEM). The practical yield of microspheres was high in ethyl cellulose and HPMC E50LV combination batch. The particle size of microspheres was found in the range of 97.51±1.45 to 267.56±8.54 µm. The SEM study reveals those microspheres are spherical in shape. Microspheres of flurbiprofen with ethyl cellulose and HPMC E50LV combination batch showed optimum drug entrapment efficiency and higher release rate as compare to other batches. The present study suggested that microsphere of flurbiprofen can be prepared using ethyl cellulose and HPMC E50LV at ratio of 1:2 of drug:polymer ratio to get sustained drug delivery. The stability study reveals that the prepared microsphere is stable.
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